Particle Engineering
Coating Place offers numerous methods of particle engineering for customers. These include high-shear granulation, fluid bed granulation, extrusion and spheronization, and milling. Particle size is an important factor in coating applications and Coating Place has the capabilities to ensure that the correct size, shape, and uniformity characteristics are created. These techniques address challenges such as poor solubility or ingredient interaction to deliver high-quality, uniform results.
Our expert formulators are here to help identify the ideal particle engineering solution for your product. With advanced Wurster fluid bed coating techniques and extensive capabilities, we’re committed to delivering the highest-quality results.
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Our high-shear granulators produce uniformly distributed wet cakes, which are extruded and spheronized into uniform spheres. These spheres are dried and coated using our proprietary CPI Wurster fluid bed coaters.
High Shear Granulation Capacity: 20 to 280L
Spheronization Capacity: 0.5 to 25kg -
We use our proprietary CPI Wurster fluid bed coaters to create granular particles that do not require additional drying after granulation. In this process, a solution is sprayed into the fluid bed coater to agglomerate the primary powder together and create larger granules by suspending the particles inside the chamber through high-velocity air. This material is then dried upon completion of the spraying by adding hot air to the unit. The particles will exit the chamber in spherical shapes due to the movement of the material in the chamber and through particle interaction.
Wurster Fluid Bed Granulation Capacity: 0.05 to 800L
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Milling improves the solubility of insoluble particles in liquid suspensions. This process breaks particles down to enhance mixing and ensure a fluidized coating with consistent viscosity. For drug-loaded suspensions, we use CPI Wurster units to spray-coat the mixture onto carrier particles, delivering smooth, uniform products with precise release profiles.