Taste Masked Technology

Taste is often a crucial factor in palatability of an oral dosage. Pharmaceutical, nutraceutical, nutritional, and other active materials typically have an objectionable taste which creates challenges for some forms of oral delivery. If it is confined to a tablet or capsule that is swallowed whole, the material can bypass the taste buds without significant detection. When the material is formulated as a chewable tablet, a fast-dissolve lozenge or film, product solution or suspension, objectionable taste is often the primary cause of patient non-compliance with a dosing requirement.

Taste masking is the ability to reduce the undesirable taste of the API during delivery. There are numerous ways to mask this unpalatable taste. Coating Place focuses on two processes which include Wurster coating and the creation of an ion exchange resin complex. Taste mask coatings typically use a common strategy involving the addition of a taste mask coating to the active material to delay release of the product until it has bypassed the mouth. This provides a physical barrier for the drug against the taste buds allowing the drug to enter the stomach or intestines before release.

The other technique used in pharmaceutical products at Coating Place is ionically binding an ionizable active to an ion exchange resin, which often neutralizes the bad taste. This ion-resin complex is typically formulated with a flavor system to mask residual or early releasing drug. Due to its insolubility to salivary conditions in this state, there is virtually no bitter taste detected. This process allows the complex to break down under gastrointestinal conditions and is absorbed through the stomach and intestines.

Coating Place has extensive experience in formulating and manufacturing taste masked products using Wurster fluid bed coating, ion exchange, and related technologies. Actives with extremely objectionable taste have been successfully taste-masked at final particle sizes as small as 40µm. Resin technology is commonly used in liquid suspensions, but can be applied to other solid dosage forms. Let Coating Place help create the right taste masking formula to make your product palatable to your customers.
Coating Place, Inc.

Our Technology

our-technologyCoating Place has been in the Wurster coating industry since its founding in 1976 with the original Wurster patent and prototype equipment from Dr. Dale Wurster. Our extensive experience allows us to guarantee efficient and effective manufacturing processes, creating optimal and high quality services for our customers.

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Oradel™ Platform

Our proprietary oral delivery technology is brought to you through our Oradel™ Platform. Our customers are offered extensive experience in the areas of modified release technology, multilayer coating and ion resin technology.

  • Oradel™-MC
  • Oradel™-XR
  • Oradel™-DR
  • Oradel™-EC
  • Oradel™-ION
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Coating Place, Inc. 200 Paoli Street PO Box 930310 Verona, WI 53593 Phone: (608) 845-9521 Fax: (608) 845-9526