(608) 845-9521
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Pharmaceutical, nutraceutical, nutritional, and other active materials typically have an objectionable taste which creates challenges for some forms of oral delivery. If it is confined to a tablet or capsule that is swallowed whole, the material can pass the taste buds without significant detection. When the material is formulated as a chewable tablet, a fast-dissolve lozenge or film, solution or suspension, objectionable taste is often the primary cause of patient non-compliance with a dosing requirement. Taste mask coatings are typically used to mask (hide) the objectionable taste in these formulations. A common taste masking strategy involves the addition of a taste mask coating to the active material to delay release of the product until it has bypassed the mouth. Another technique used in pharmaceutical products is to ionically bind an ionizable active to an ion-exchange resin; the ionic bond often neutralizes the bad taste. This ion-resin complex is typically formulated with a flavor system to mask residual or early releasing drug. Coating Place has extensive experience in formulating and manufacturing taste-masked products using Wurster fluid bed coating, ion-exchange, and related technologies. Actives with extremely objectionable taste have been successfully taste-masked at final nominal particle sizes as small as ~40µm. Resin technology is commonly used in liquid suspensions, but can be applicable to other solid dosage forms. |
THE WURSTER PROCESS
NEWS AND EVENTS
DID YOU KNOW?
- Coating Place has over 30 years of experience developing ion-exchange products.
Coating Place, Inc. 200 Paoli Street | PO Box 930310 | Verona, WI 53593. Phone: (608) 845-9521 Fax: (608) 845-9526
